Use of a genomic test (MammaPrint) in daily clinical practice to assist in risk stratification of young breast cancer patients

Publication Name: Archives of Gynecology and Obstetrics

Author(s): Georg Kunz

Purpose: Breast cancer as a heterogeneous disease demands reliable tools in order to identify those patients who most likely will benefit from receiving adjuvant treatment, such as chemotherapy. MATERIALS AND METHODS: The MammaPrint test was established on the basis of … Continued

The predictive value of the 70-gene signature for adjuvant chemotherapy in early breast cancer

Publication Name: Breast Cancer Research and Treatment

Author(s): Michael Knauer, Stella Mook, Emiel J. T. Rutgers, Richard A. Bender, Michael Hauptmann, Marc J. van de Vijver, Rutger H. T. Koornstra, Jolien M. Bueno-de-Mesquita, Sabine C. Linn, Laura J. van ’t Veer

Multigene assays have been developed and validated to determine the prognosis of breast cancer. In this study, we assessed the additional predictive value of the 70-gene MammaPrint signature for chemotherapy (CT) benefit in addition to endocrine therapy (ET) from pooled … Continued

MammaPrint® translating research into a diagnostic test, Molecular Diagnostics, The Key Driver in Personalized Cancer Medicine

Publication Name: CMC Contrast, Denmark) & Henrik Winther (Dako, Denmark) Pan Stanford Publihing

Author(s): Annuska M Glas, Leonie Delahaye and Oscar Krijgsman

Gene expression profiles that provide clinical utility have been developed in the last decade. However, only a handful are currently available for broad clinical use through commercial enterprises. Once a test does enter the clinical setting it is imperative to … Continued

The future of diagnostic microarrays; bridging the gap between bench and bedside.

Publication Name: Bioanalysis

Author(s): Roepman, Paul

During the last two decades, an increasing number of microarray studies have identified gene-expression profiles that link disease characteristics to patient outcome. However, despite improvements in technology and the clinical relevance of the identified profiles, only a handful of microarray … Continued