Clinical Application of the 70-Gene Profile: The MINDACT Trial

Publication Name: Journal of Clinical Oncology

Author(s): Cardoso F1, Van't Veer L, Rutgers E, Loi S, Mook S, Piccart-Gebhart MJ

The 70-gene profile is a new prognostic tool that has the potential to greatly improve risk assessment and treatment decision making for early breast cancer. Its prospective validation is currently ongoing through the MINDACT (Microarray in Node-Negative Disease May Avoid Chemotherapy) trial, a 6,000-patient randomized, multicentric trial. This article reviews the several steps in the development of the profile from its discovery to its clinical validation. See article.