Microarray analysis and tumor classification.

Publication Name: New England Journal of Medicine

Author(s): J. Quackenbush, Ph.D.

DNA microarray analysis was first described in the mid-1990s as a means to probe the expression of thousands of genes simultaneously(1,2) and was quickly adopted by the research community for the study of a wide range of biologic processes. Most of the early studies had a simple and powerful design: to compare two biologic classes in order to identify the differential expression of the genes in them — genes with potential relevance to a wide range of biologic processes, such as the progression of cancer,(3-6) the causes of asthma,(7-9) heart disease,(10-12) and neuropsychiatric disorders,(13-17) and the analysis of factors associated.

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