Molecular Portraits and 70-Gene Prognosis Signature Are Preserved throughout the Metastatic Process of Breast Cancer

Publication Name: The Journal of Cancer Research

Author(s): Britta Weigelt, Zhiyuan Hu, Xiaping He, Chad Livasy, Lisa A. Carey, Matthew G. Ewend, Annuska M. Glas, Charles M. Perou and Laura J. van't Veer

Microarray analysis has been shown to improve risk stratification of breast cancer. Breast tumors analyzed by hierarchical clustering of expression patterns of “intrinsic” genes have been reported to subdivide into at least four molecular subtypes that are associated with distinct … Continued

Molecular Portraits of Human Breast Tumours

Publication Name: Nature

Author(s): Charles M. Perou, Therese Sùrlie, Michael B. Eisen, Matt van de Rijn, Stefanie S. Jeffreyk, Christian A. Rees

Human breast tumours are diverse in their natural history and in their responsiveness to treatments1. Variation in transcriptional programs accounts for much of the biological diversity of human cells and tumours. In each cell, signal transduction and regulatory systems transduce … Continued