Molecular subtyping of early-stage breast cancer identifies a group of patients who do not benefit from neoadjuvant chemotherapy

Publication Name: Breast Cancer Research and Treatment

Author(s): Stefan Glück, Femke de Snoo, Justine Peeters, Lisette Stork-Sloots, George Somlo

The aim of this study was to analyze the correlation between the pathologic complete response (pCR) rate after neoadjuvant chemotherapy and long-term outcome (distant metastases-free survival [DMFS]) in patients with early-stage breast cancer using BluePrint and MammaPrint molecular subtyping versus … Continued

Combining multigene profiling of molecular subtypes with the 70-gene profile for classification of breast cancer

Publication Name: Abstract, ASCO 2009

Author(s): Stork-Sloots L, Krijgsman O, Roepman P, et al. Combining multigene profiling of molecular subtypes with the 70-gene profile for classification of breast cancer. J Clin Oncol 2009; 27: 15s

Background: Classification of breast cancers into molecular subtypes may be important for accurate selection of therapy for patients. Herein we report a multigene profile for classification of breast cancer into molecular subtypes. The profile separates tumors into hormone receptor (HR)+/luminal-like, HER2+/ERBB2-like, … Continued