First generation prognostic gene signatures for breast cancer predict both survival and chemotherapy sensitivity and identify overlapping patient populations

Publication Name: Breast Cancer Res Treat

Author(s): Takayuki Iwamoto, Ju-Seog Lee. Giampaolo Bianchini, Rebekah E. Hubbard

The aims of this study were to compare the performance of six different genomic prognostic markers to predict long-term survival and chemotherapy response on the same patient cohort and assess if clinicopathological variables carry independent prognostic and predictive values. We … Continued

A diagnostic gene profile for molecular subtyping of breast cancer associated with treatment response

Publication Name: Breast Cancer Research and Treatment

Author(s): Oscar Krijgsman, Paul Roepman, Wilbert Zwart, Jason S. Carroll, Sun Tian, Femke A. de Snoo, Richard A. Bender, Rene Bernards, Annuska M. Glas

Classification of breast cancer into molecular subtypes maybe important for the proper selection of therapy, as tumors with seemingly similar histopathological features can have strikingly different clinical outcomes. Herein, we report the development of a molecular subtyping profile (BluePrint), that … Continued

The 70-gene signature as a response predictor for neoadjuvant chemotherapy in breast cancer.

Publication Name: Breast Cancer Research and Treatment

Author(s): Marieke E. Straver, Annuska M. Glas, Juliane Hannemann, Jelle Wesseling, Marc J. van de Vijver, Emiel J. Th. Rutgers, Marie-Jeanne T. F. D. Vrancken Peeters, Harm van Tinteren, Laura J. van‘t Veer, Sjoerd Rodenhuis

The 70-gene signature (MammaPrintTM) is a prognostic tool used to guide adjuvant treatment decisions. The aim of this study was to assess its value to predict chemosensitivity in the neoadjuvant setting. We obtained the 70-gene profile of stage II–III patients … Continued