A prospective evaluation of a breast cancer prognosis signature in the observational RASTER study

Publication Name: International Journal of Cancer

Author(s): C.A. Drukker, J.M. Bueno-de-Mesquita, V.P. Retèl, W.H. van Harten, H. van Tinteren, J. Wesseling, R.M.H. Roumen, M. Knauer, L.J. van ’t Veer, G.S. Sonke, E.J.T. Rutgers, M.J. van de Vijver, S.C. Linn

The 70-gene signature (MammaPrint™) has been developed on retrospective series of breast cancer patients to predict the risk of breast cancer distant metastases. The microarRAy-prognoSTics-in-breast-cancER (RASTER) study was the first study designed to prospectively evaluate the performance of the 70-gene … Continued

RASTER: First-Ever Prospective Diagnostic Study in Breast Cancer

Publication Name: Press Release

RASTER Five-Year Follow-Up Data Indicates Chemotherapy May Be Safely Withheld for Patients Deemed ‘Low Risk’ for Breast Cancer Recurrence Using Agendia’s MammaPrint Test, Data Presented at European Breast Cancer Conference IRVINE, CA and AMSTERDAM, THE NETHERLANDS, March 22, 2012 – … Continued

Use of a 70-Gene Signature to predict prognosis of patients with node-negative breast cancer: a prospective community-based feasibility study (RASTER).

Publication Name: Lancet Oncology

Author(s): Jolien M Bueno-de-Mesquita MD, Prof Wim H van Harten MD, Valesca P Retel MSc, Laura J van 't Veer PhD, Prof Frits SAM van Dam PhD, Kim Karsenberg MSc, Kirsten FL Douma MSc, Harm van Tinteren PhD, Johannes L Peterse MD, Jelle Wesseling MD, Tin S Wu MSc, Douwe Atsma BSc, Prof Emiel JT Rutgers MD, Guido Brink BSc, Arno N Floore BSc, Annuska M Glas PhD, Rudi MH Roumen MD, Frank E Bellot MD, Cees van Krimpen MD, Prof Sjoerd Rodenhuis MD, Prof Marc J van de Vijver MD, Dr Sabine C Linn MD

Background: A microarray-based 70-gene prognosis signature [MammaPrint] might improve the selection of patients with node-negative breast cancer for adjuvant systemic treatment. The main aims of this MicroarRAy PrognoSTics in Breast CancER (RASTER) study were to assess prospectively the feasibility of … Continued