Evidence

Role of Patient and Disease Factors in Adjuvant Systemic Therapy Decision Making for Early-Stage, Operable Breast Cancer: Update of the ASCO Endorsement of the Cancer Care Ontario Guideline

August 1, 2019

PUBLICATION: Journal of Clinical Oncology 37, no. 22 (August 01, 2019) 1965-1977. DOI: 10.1200/JCO.19.00948. AUTHORS: N. Lynn Henry, MD, PhD; Mark R. Somerfield, PhD; Vandana G. Abramson, MD; Nofisat Ismaila, MD; Kimberly H. Allison, MD; Carey K. Anders, MD; Diana T. Chingos, MS, MFA; Andrea Eisen, MD; Bruno L. Ferrari, MD; Thomas H. Openshaw, MD; Patricia A.…

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Impact of 70-Gene Signature Use on Adjuvant Chemotherapy Decisions in Patients With Estrogen Receptor–Positive Early Breast Cancer: Results of a Prospective Cohort Study

August 20, 2017

PUBLICATION: Journal of Clinical Oncology 35, no. 24 (August 20, 2017) 2814-2819. DOI: 10.1200/JCO.2016.70.3959. AUTHORS: Anne Kuijer, Marieke Straver, Bianca den Dekker, Annelotte C.M. van Bommel, Sjoerd G. Elias, Carolien H. Smorenburg, Jelle Wesseling, Sabine C. Linn, Emiel J.Th. Rutgers, Sabine Siesling, and Thijs van Dalen SUMMARY: Prospective, observational Dutch study with ER-positive, early-stage breast cancer, 70-GS use…

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Clinical Application of the 70-gene Profile: The MINDACT Trial

February 11, 2008

PUBLICATION: J Clin Oncol. 2008 Feb 10;26(5):729-35. doi: 10.1200/JCO.2007.14.3222. AUTHORS: Cardoso F., Van’t Veer L., Rutgers E., Loi S., Mook S., Piccart-Gebhart M.J. SUMMARY: Its prospective validation is currently ongoing through the MINDACT (Microarray in Node-Negative Disease May Avoid Chemotherapy) trial, a 6,000-patient randomized, multicentric trial. This article reviews the several steps in the development of the profile…

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Gene Expression Profiling of Breast Cancer: A New Tumor Marker

March 10, 2005

PUBLICATION: Journal of Clinical Oncology March 10, 2005 23:8, 1631-1635 AUTHORS: Laura J. van’t Veer, Soonmyung Paik, Daniel F. Hayes SUMMARY: A review of genomic signatures and the genomic landscape. Read more: van’t Veer et al_2005_Journal of Clinical Oncology._Gene Expression Profiling  

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