Evidence

Prognostic Value of MammaPrint® in Invasive Lobular Breast Cancer

December 11, 2016

PUBLICATION: Biomark Insights. 2016; 11: 139–146. doi: 10.4137/BMI.S38435 AUTHORS: Inès J. Beumer, Marion Persoon, Anke Witteveen, Christa Dreezen, Suet-Feung Chin, Stephen-John Sammut, Mireille Snel, Carlos Caldas, Sabine Linn, Laura J. van ’t Veer, Rene Bernards, and Annuska M. Glas SUMMARY: Pooled analysis. Study results validate MammaPrint as an independent factor for breast cancer patients with early-stage invasive lobular…

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Genomic Profiling of Breast Cancer in African-American Women Using MammaPrint.

August 27, 2016

PUBLICATION: Breast Cancer Res Treat (2016) 159: 481. https://doi.org/10.1007/s10549-016-3949-y09. AUTHORS: Raquel A. Nunes, Lynette Wray, Mihriye Mete, Pia Herbolsheimer, Karen L. Smith, Lana Bijelic, Marc E. Boisvert, Sandra M. Swain SUMMARY: We evaluated gene expression in tumors from AAF presenting with early stage or locally advanced breast cancer using MammaPrint, BluePrint (molecular subtype) and TargetPrint, correlated with OncotypeDX…

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70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer

August 25, 2016

PUBLICATION: N Engl J Med 2016; 375:717-729; DOI: 10.1056/NEJMoa1602253. AUTHORS: Fatima Cardoso, M.D., Laura J. van’t Veer, Ph.D., Jan Bogaerts, Ph.D., Leen Slaets, Ph.D., Giuseppe Viale, M.D., Suzette Delaloge, M.D., Jean-Yves Pierga, M.D., Ph.D., Etienne Brain, M.D., Ph.D., Sylvain Causeret, M.D., Mauro DeLorenzi, Ph.D., Annuska M. Glas, Ph.D., Vassilis Golfinopoulos, M.D., Ph.D., et al., for the MINDACT…

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MINDACT Supplementary Appendix NEJM 2016

August 15, 2016

SUPPLEMENTARY APPENDIX: This appendix has been provided by the authors to give readers additional information about their work. Supplement to: Cardoso F., van’t Veer L.J., Bogaerts J., et al. 70-Gene signature as an aid to treatment decisions in early-stage breast cancer. N Engl J Med 2016;375:717-29. DOI: 10.1056/NEJMoa1602253.   Read more: MINDACT Supplementary Appendix_NEJM 2016…

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Genomic Impact of Neoadjuvant Therapy on Breast Cancer: Incomplete Response is Associated with Altered Diagnostic Gene Signatures

July 6, 2016

PUBLICATION: Ann Surg Oncol (2016) 23: 3317. https://doi.org/10.1245/s10434-016-5329-6. AUTHORS: Peter Beitsch, Pat Whitworth, Paul Baron, James Pellicane, Tina Treece, Erin Yoder, Mark Gittleman, NBRST Investigators Group SUMMARY: This substudy showed that NAT significantly altered the genomic signature of the patient’s breast cancer compared with the patient’s pre-treatment genomic profile. These alterations occurred in a subtype-dependent manner, suggesting that…

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Breast Cancer: Determining the Genetic Profile from Ultrasound-Guided Percutaneous Biopsy Specimens Obtained During Diagnostic Workups

June 14, 2016

PUBLICATION: Radiología (English Edition) Volume 58, Issue 3, May–June 2016, Pages 214-220. AUTHORS: J.A. López Ruiz, I.Zabalza Estévez, J.A. Mieza Arana SUMMARY: Small study demonstrating feasbility of MP on FFPE core biopsies -13 patients. Read more: López Ruiz et al_2016_Radiología_Breast Cancer: Determining the Genetic Profile…  

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Cáncer de Mama: Determinación del Perfil Genético a Partir de la Biopsia Percutánea Ecoguiada Diagnóstica

June 1, 2016

PUBLICATION: Radiología; Vol. 58. Issue 3. pages 214-220 (May-June 2016) AUTHORS: J.A. López Ruiza, I. Zabalza Estévezb, J.A. Mieza Aranac PUBLICATION TITLE (English): Breast cancer: determining the genetic profile from ultrasound-guided percutaneous biopsy specimens obtained during the diagnostic workups ABSTRACT: Objectives: To evaluate the possibility of determining the genetic profile of primary malignant tumors of the breast from specimens…

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Impact of Tumor Size on Probability of Pathologic Complete Response After Neoadjuvant Chemotherapy

May 1, 2016

PUBLICATION: Ann Surg Oncol (2016) 23: 1522. https://doi.org/10.1245/s10434-015-5030-1. AUTHORS: Paul Baron, Peter Beitsch, Danielle Boselli, James Symanowski, James V. Pellicane, Jennifer Beatty, Paul Richards, Angela Mislowsky, Charles Nash, Laura A. Lee, Mary Murray, Femke A. de Snoo, Lisette Stork-Sloots, Mark Gittleman, Stephanie Akbari, Pat Whitworth SUMMARY: We found that although size was correlated inversely with the frequency of…

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Equivalence of MammaPrint Array Types in Clinical Trials and Diagnostics

March 22, 2016

PUBLICATION: Breast Cancer Res Treat (2016) 156: 279. https://doi.org/10.1007/s10549-016-3764-5 AUTHORS: Inès Beumer, Anke Witteveen, Leonie Delahaye, Diederik Wehkamp, Mireille Snel, Christa Dreezen, John Zheng, Arno Floore, Guido Brink, Bob Chan, Sabine Linn, Rene Bernards, Laura van ’t Veer, Annuska Glas SUMMARY: Here we demonstrate the equivalence and reproducibility of the MammaPrint test on both customized certified array types,…

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