Evidence

Converting a Breast Cancer Microarray Signature into a High-Throughput Diagnostic Test

October 30, 2006

PUBLICATION: BMC Genomics. 2006 Oct 30;7:278. AUTHORS: Glas A.M., Floore A., Delahaye L.J., Witteveen A.T., Pover R.C., Bakx N., Lahti-Domenici J.S., Bruinsma T.J., Warmoes M.O., Bernards R., Wessels L.F., Van’t Veer L.J. SUMMARY: In this report, we demonstrate for the first time that microarray technology can be used as a reliable diagnostic tool. The data clearly demonstrate the…

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Gene Expression Profiles of Primary Breast Carcinomas from Patients at High-Risk for Local Recurrence After Breast-Conserving Therapy

October 1, 2006

PUBLICATION: Clin Cancer Res. 2006 Oct 1;12(19):5705-12. AUTHORS: Kreike B., Halfwerk H., Kristel P., Glas A., Peterse H., Bartelink H., van de Vijver M.J. SUMMARY: No significant differences in gene expression between primary breast cancer tumors in patients with or without local recurrence after BCT were identified. Furthermore, analyses of primary tumors and local recurrences show a preservation…

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Validation and Clinical Utility of a 70-Gene Prognostic Signature for Women with Node-Negative Breast Cancer

September 6, 2006

PUBLICATION: J Natl Cancer Inst. 2006 Sep 6;98(17):1183-92. AUTHORS: Buyse M., Loi S., van’t Veer L., Viale G., Delorenzi M., Glas A.M., d’Assignies M.S., Bergh J., Lidereau R., Ellis P., Harris A., Bogaerts J., Therasse P., Floore A., Amakrane M., Piette F., Rutgers E., Sotiriou C., Cardoso F., Piccart M.J.; TRANSBIG Consortium. SUMMARY: The 70-gene signature outperformed the…

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