Evidence

Identification of a Low-Risk Subgroup of HER-2-Positive Breast Cancer by the 70-gene Prognosis Signature

December 7, 2010

PUBLICATION: Br J Cancer. 2010 Dec 7; 103(12): 1788–1793. Published online 2010 Nov 16. doi: 10.1038/sj.bjc.6605916. AUTHORS: M. Knauer, F. Cardoso, J. Wesseling, P.L. Bedard, S.C. Linn, E.J.T. Rutgers, and L.J. van’t Veer SUMMARY: Pooled analysis: In the group of 89 chemotherapy-naive patients, after a median follow-up of 7.4 years, 35 (39%) distant recurrences and 29 (33%) breast…

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The Predictive Value of the 70-Gene Signature for Adjuvant Chemotherapy in Early Breast Cancer

March 5, 2010

PUBLICATION: Breast Cancer Res Treat. 2010 Apr;120(3):655-61. doi: 10.1007/s10549-010-0814-2. AUTHORS: Knauer M., Mook S., Rutgers E.J., Bender R.A., Hauptmann M., van de Vijver M.J., Koornstra R.H., Bueno-de-Mesquita J.M., Linn S.C., van ‘t Veer L.J. ABSTRACT: Multigene assays have been developed and validated to determine the prognosis of breast cancer. In this study, we assessed the additional predictive value…

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Gene Expression Profiling in Breast Cancer – Design of a Pooled Database to Address Open Questions

October 1, 2009

PUBLICATION: Eur Surg (2009) 41: 221. https://doi.org/10.1007/s10353-009-0487-4. AUTHORS: M. Knauer, E. Wenzl, E.J.T. Rutgers, S.C. Linn, L.J. van’t Veer SUMMARY: A pooled database was constructed containing clinical, pathological and microarray data of 1696 patients. The database will be used to study the performance of the 70-gene profile in patients with small-sized T1 tumors. Read more: Knauer et al_2009_European…

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