February 1, 2010

The 70-gene Signature as a Response Predictor for Neoadjuvant Chemotherapy in Breast Cancer

PUBLICATION: 
Breast Cancer Res Treat. 2010 Feb;119(3):551-8. doi: 10.1007/s10549-009-0333-1. Epub 2009 Feb 13.

AUTHORS: 
Straver M.E., Glas A.M., Hannemann J., Wesseling J., van de Vijver M.J., Rutgers E.J., Vrancken Peeters M.J., van Tinteren H., Van’t Veer L.J., Rodenhuis S.

SUMMARY: 
144 (86%) were having a poor and 23 (14%) a good prognosis-signature. None of the good prognosis-signature patients achieved a pCR (0/23), whereas 29/144 patients (20%) in the poor prognosis-signature group did (P = 0.015).

Read more: Straver et al_2010_Breast Cancer Research and Treatment_The 70-gene Signature