December 5, 2018

New Research to be Presented at SABCS 2018 Reinforces MammaPrint and BluePrint Testing to Guide Breast Cancer Treatment Management Decisions

PRESS RELEASE

Agendia Announces New Research Reinforcing MammaPrint® and BluePrint® Testing to Guide Breast Cancer Treatment Management Decisions Across Different Patient Populations and Ages at the 2018 San Antonio Breast Cancer Symposium

IRVINE, CA, AMSTERDAM, NETHERLANDS – 28 November 2018 – Agendia, Inc., a world leader in precision oncology, will present new data reinforcing the utility of its MammaPrint® 70-Gene Breast Cancer Risk of Recurrence and BluePrint® Breast Cancer Molecular Subtyping tests at the 2018 San Antonio Breast Cancer Symposium (SABCS). A total of 14 posters and discussions are being presented at SABCS, which will take place at the Henry B. Gonzales Convention Center in San Antonio, Texas from Dec. 4-8, 2018.

Data outlining the cost-effectiveness and economic impact of MammaPrint, as well as performance data of MammaPrint and BluePrint in real-world diagnostic and decentralized testing settings across different patient populations, including HER2-positive cancer and those affected by metabolic syndrome, will be presented.

A highlight will be the poster session on Friday, Dec. 7, which will show that MammaPrint reclassifies 46 percent of patients aged 50 or younger with intermediate recurrence scores (RS 18-30) according to the 21-gene assay as MammaPrint Low Risk, suggesting they are unlikely to benefit from chemotherapy.

Important data from the following studies will also be presented:

Dr. William Audeh, Chief Medical Officer at Agendia, said:

“The wealth of new clinical and genomic data presented at SABCS adds to an already significant body of evidence supporting the use of MammaPrint and BluePrint to help physicians and breast cancer patients around the world make informed treatment decisions.

“As these new data will show, MammaPrint and BluePrint continue to offer expanded utility for patients of all ages, whether lymph node-negative or lymph node-positive, with lobular cancer, in neoadjuvant therapy and across different technologies. Of particular interest will be the unique genomic data in cancers identified as HER2 “equivocal” by pathology. The use of MammaPrint and BluePrint in breakthrough trials such as I-SPY 2, which will also report new data at SABCS, is testament to the quality and robustness of the science that underpins these tests. It is becoming increasingly clear that genomic testing offers a path to more personalized medicine in breast cancer, and we are proud that our tests are at the forefront of this effort.”

Abstracts are available to view on the SABCS website.  For more information please visit the Agendia team at booth #607.

Wednesday, Dec. 5

Thursday, Dec. 6

Friday, Dec. 7

About MammaPrint®

MammaPrint is an in vitro diagnostic medical device, performed as a testing service in a central laboratory, using the 70-gene expression profile of breast cancer tissue samples to assess a patient’s risk for distant metastasis. The device is FDA-cleared and CE-marked, enabling use in the European Union. MammaPrint is indicated for use by physicians as a prognostic marker only, along with other clinical-pathological factors. It is not intended to determine the outcome of disease, nor to suggest or infer an individual patient’s response to therapy.

About BluePrint®

BluePrint is an 80-gene complementary test provided with MammaPrint which allows functional molecular subtyping of a breast cancer sample into three distinct subtypes: Luminal-type, HER2-type and Basal-type, each with marked differences in long-term outcome and response to neoadjuvant chemotherapy.

About Agendia

Agendia is a privately held, leading precision oncology company that develops and markets genomic diagnostic products, which help support physicians with their complex treatment decisions. Agendia’s breast cancer tests were developed using an unbiased gene selection by analyzing the complete human genome. The company’s offerings include the MammaPrint Breast Cancer Risk-of-Recurrence Test, and the BluePrint Molecular Subtyping Test, both on microarray technology, whereas the new MammaPrint BluePrint Breast Cancer Recurrence and Molecular Subtyping Kit, is on NGS technology.

The MammaPrint BluePrint next-generation sequencing-based kit is a CE-marked device currently available for use in cancer centers in select regions of the world.

In addition, Agendia has a pipeline of other genomic products in development. The company collaborates with pharmaceutical companies, leading cancer centers and academic groups to develop companion diagnostic tests in the area of oncology. For more information on Agendia or the MammaPrint and BluePrint tests, visit www.agendia.com. Follow Agendia, Inc. on Facebook, Twitter, or LinkedIn to keep up-to-date with the latest news.

Media Contacts

Agendia

Weber Shandwick

Heather Platisha

+1 (206) 576-5558

[email protected]